Different Effects of Valproic Acid on Photoreceptor Loss in Rd1 and Rd10 Retinal Degeneration Mice.

Different Effects of Valproic Acid on Photoreceptor Loss in Rd1 and Rd10 Retinal Degeneration Mice. in Molecular Vision.  http://www.molvis.org/molvis/v20/1527/

Using retinal degeneration mouse strains, this paper’s data demonstrate that the underlying etiology of the photoreceptor degeneration is important to determining the effects of Valproic Acid (VPA) on the rate of photoreceptor loss. Our results are very important, because off-label VPA clinical trials with Human RP patients are underway in the USA and South Korea. Thus, VPA might help some families, but not others, depending on the exact genetic mutation, and thus disease etiology, involved in their RP. Our study with mice would indicate that any clinical trials should make comparisons of VPA to placebo within RP patients who have the same disease etiology (same genetic mutation). Patients should also be monitored very closely to evaluate changes in the rate of visual field loss and visual acuity loss while taking VPA in such trials. Continue reading

Advertisements